Direct Meds
Featured PartnerCash-pay telehealth brand selling compounded GLP-1s, HRT, longevity injectables and a rapid-dissolve ED tablet, filled by named partner pharmacies.
Our Verdict
Direct Meds scores 74.5/100 in our independent evaluation — good overall, standing out most for value. It holds our “Best No-Membership ED Option” label. Plans start at $53/mo.
What we like
What to watch
Full Review
Direct Meds is a cash-pay telehealth brand: its clinicians prescribe, and two named partner 503A pharmacies, CraftedRx (Warrenton, MO) and ChemistryRx (Folcroft, PA), fill orders by patient location. It markets straightforward cash-pay access, but its marketing pages publish only a couple of prices, with the rest on a separate storefront, and its GLP-1 tiers carry a three-month billing commitment.
Last researched: Sep 26, 2026 · Prices checked: Oct 9, 2026
Direct Meds GLP-1 pricing: month 1 vs. month 2+
The advertised price is often only the first month. This is what each plan costs once intro pricing ends.
All-in prices: medication plus any required membership. Verified 2026-09-26. Model your own year →
| Plan | Month 1 | Month 2+ | Year one | What to know |
|---|---|---|---|---|
| Compounded Semaglutide (sublingual) Compounded | $249 | $237–$249/mo | $2,856–$2,988 | No price jump after month 1Same price at every dose $249 month-to-month; $237/mo equivalent on a 90-day pack |
| Compounded Semaglutide (injectable) Compounded | $297 | $297/mo | $3,564 | No price jump after month 1Same price at every dose |
| Compounded Tirzepatide (sublingual) Compounded | $299 | $299/mo | $3,588 | No price jump after month 1Same price at every dose |
| Compounded Tirzepatide (injectable) Compounded | $399 | $399/mo | $4,788 | No price jump after month 1Same price at every dose |
Pricing
Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.
| Treatment | Category | Price/mo | Includes | Notes |
|---|---|---|---|---|
| Women's HRT (Nuvella): estradiol, progesterone, DHEA | Hormone Therapy | $180–$197 | ● Consults○ Lab work● Shipping | $540 for the first 3 months, then $180/mo Subscription required |
| DirectMax rapid-dissolve ED tablet (apomorphine + sildenafil + tadalafil) | Sexual Health | $53–$216 | ● Consults○ Lab work● Shipping | 33% off first order (from $7.45/dose) No subscription needed |
| Sermorelin Injections | Longevity & Peptides | $299 | ● Consults○ Lab work● Shipping | $100 off first order Subscription required |
| Tesamorelin Injections | Longevity & Peptides | $349 | ● Consults○ Lab work● Shipping | $100 off first month ($249) Subscription required |
| Compounded Semaglutide (sublingual) | Weight Loss / GLP-1 | $237–$249 | ● Consults○ Lab work● Shipping | $237/mo equivalent on a 90-day pack; $249/mo monthly Subscription required |
| Compounded Semaglutide (injectable) | Weight Loss / GLP-1 | $297 | ● Consults○ Lab work● Shipping | Subscription required |
| NAD+ Injections | Longevity & Peptides | $199–$299 | ● Consults○ Lab work● Shipping | Up to $100 off shown as strike-through pricing; no first-month rate Subscription required |
| Compounded Tirzepatide (injectable) | Weight Loss / GLP-1 | $399 | ● Consults○ Lab work● Shipping | Subscription required |
| Compounded Tirzepatide (sublingual) | Weight Loss / GLP-1 | $299 | ● Consults○ Lab work● Shipping | Subscription required |
Where Direct Meds medication comes from
Direct Meds' Dec 2025 press release names CraftedRx (Warrenton, MO) and ChemistryRx (Folcroft, PA) as its 503A pharmacies, assigned by patient location.
Score Breakdown
How Direct Meds Stacks Up
Direct Meds — Frequently Asked Questions
Is Direct Meds legit?
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We rate Direct Meds's trust & safety at 72/100 (good), based on FDA compliance, licensing, and pricing transparency. Its overall score across all five of our scoring dimensions is 74.5/100 — see the full breakdown above.
How much does Direct Meds cost?
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Direct Meds's plans start at $53/mo. Exact pricing varies by treatment — see the pricing table above for a breakdown by product. Prices were last verified 2026-09-26.
Does Direct Meds require a subscription?
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It depends on the plan. Some Direct Meds treatments require an ongoing subscription and some don't — check the "Notes" column in the pricing table above.
What does Direct Meds treat?
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Direct Meds offers treatment in: Weight Loss / GLP-1, Men's Health, Sexual Health, Longevity & Peptides, Hormone Therapy, Women's Health. It holds our “Best No-Membership ED Option” label.